Welcome to the Robert lab! We are dedicated at understanding the molecular mechanisms behind transcription by RNA polymerase II, the enzyme responsible for the transcription of all protein-coding genes as well as several non-coding RNAs. We apply functional genomic and proteomic approaches to our favorite model organism, the budding yeast Saccharomyces cerevisiae.
We are located at IRCM, a research institute affiliated with Université de Montréal and also in partnership with McGill University. We train postdocs and graduate students from both Universities.
Congratulations to Pierre Collin who successfully defended his thesis.
The Robert Lab received new funding from the CIHR.
Our recent work on FACT and Spt6 is out!
Collin P, Jeronimo C, Poitras C, Robert F. (2019) RNA Polymerase II CTD Tyrosine 1 Is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway. Mol Cell. 2019 Jan 10 doi.org/10.1016/j.molcel.2018.12.002.
Uwimana N, Collin P, Jeronimo C, Haibe-Kains B, Robert F. (2017) Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes. Nucleic Acids Res. 45(11):6417-6426.
Jeronimo C, Langelier MF, Bataille AR, Pascal JM, Pugh BF, Robert F. (2016) Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo. Mol Cell. 64(3):455-466.
Jeronimo C, Watanabe S, Kaplan CD, Peterson CL, Robert F. The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations. Mol Cell. 2015 Jun 18;58(6):1113-23.
Jeronimo C, Robert F. Kin28 regulates the transient association of Mediator with core promoters. Nat Struct Mol Biol. 2014 May;21(5):449-55.
Bataille AR, Jeronimo C, Jacques PÉ, Laramée L, Fortin MÈ, Forest A, Bergeron M, Hanes SD, Robert F. A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes. Mol Cell. 2012 Jan 27;45(2):158-70.
A complete list can be found here.